UTI Facts

-About 50% of women will experience a UTI at some point,

-About 25% will go on to develop recurrent infections within 6 months of the initial infection

- There appears to be some genetic susceptibility, based on family studies

- UTIs account for 9% of antibiotics prescribed each year, with antibiotic resistance a growing concern

- 1% of UTIs will become kidney infections

- UTIs have been associated with relapses in brain disorders such as schizophrenia and dementia, for reasons that are unclear

- 80-90% of UTIs are estimated to be E. Coli

- Bacteria vaginosis caused by Gardnerella vaginalis is associated with increased risk of UTIs, likely due to damage it causes to the cells in the bladder wall

- Bacteria that attach and multiply on the walls of the bladder form a biofilm, a colony which resists the immune system

- Finger-like projections in bacteria grab hold of the sugars in the bladder wall and hold on while antibiotics flush free-floating bacteria

- D-mannose appears to work by providing another sugar in the urine which the E. coli grab onto (rather than the sugar in the cell walls), allowing them to be flushed out.

- Typical dose (maintenance or as-needed) of D-mannose is 2 g per day. It can be stirred into liquids and has a mild sweet taste.

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